Amy Schumer, 44, says she isn’t feeling “very sexual” after describing a “botched colonoscopy.” She also previously tied her health journey to an exogenous Cushing syndrome diagnosis and has spoken about steroid injections, steroid-related “moon face,” and lat
Amy Schumer is choosing candor over image, even when the subject is uncomfortable. During a “Not Skinny But Not Fat” podcast event with Dear Media, the comedian said she feels happier than she ever has been, but added that she isn’t in the mood for romance.
“I actually had, kind of, a botched colonoscopy, so I’m not feeling very sexual,” Schumer, 44, said.. A colonoscopy is an outpatient procedure in which a doctor examines the large intestine through a microscopic camera to screen for colorectal cancer.. She did not offer additional details about what she described as the mishap.
Her comments land on top of a longer public health narrative.. In a 2024 issue of the “News Not Noise” newsletter. Schumer wrote. “I feel reborn. ” after confirming she had been diagnosed with exogenous Cushing syndrome.. She wrote that “There are a few types of Cushing.. Some that can be fatal, require brain surgery or removal of adrenal glands.”
Cushing syndrome is often described as a condition that can be triggered by high-dose steroid injections and is characterized by a round. red and full face. as well thin skin and weight gain.. The story Schumer has shared centers on how she believed the diagnosis started with medical treatment—and how attention online later connected the dots for her.. She has said she was getting steroid injections. and that it led to Cushing syndrome. “which I wouldn’t have known if the internet hadn’t come for me so hard.”
On the “Call Her Daddy” podcast in 2025. she said she learned about “moon face” while preparing to appear on camera in a movie. and described how the online chatter affected her.. “I was feeling really down on myself before I started filming this movie,” she said.. She also said that once she began to feel better—supported by her friends—the swelling began to dissolve on its own.
As her health story continued, Schumer also discussed weight-loss medication.. She has been on a weight loss journey, and she said she has relied on GLP-1 medications.. In a March 2025 social media video, she said, “Three years ago, I tried Wegovy.. I was puking, I couldn’t handle it.. I don’t know if they’ve changed the formula. whatever.” She added that she later attended a Telehealth meeting with Midi Health. describing it as “cheap. ” and said she decided to try it herself to recommend it to friends who are nurses and teachers.
In that same March 2025 video. Schumer said the telehealth provider put her on estrogen and progesterone because she realized she was in perimenopause. and she said her perimenopause symptoms disappeared after that change.. She said. “My hair is fuller. my skin is better. I have more energy. I want to get down more. ” and then linked those improvements to her desire for sex: “I’m talking about sex.. So that’s been great and Mounjaro’s been great.”
The thread running through her statements is a sequence of medical events and follow-up changes: steroid injections tied to exogenous Cushing syndrome. online pressure that helped her recognize “moon face. ” swelling that began to dissolve as she felt better. and then later weight-loss and hormone steps that she says brought back energy and helped with symptoms—while her more recent “botched colonoscopy” is where she places her current lack of sexual desire.
At the center of her personal life, Schumer is currently separated from estranged husband Chris Fischer, with whom she shares son Gene.
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